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1

TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells

Mariathasan, Sanjeev, Turley, Shannon J., Nickles, Dorothee, Castiglioni, Alessandra, Yuen, Kobe, Wang, Yulei, Kadel III, Edward E., Koeppen, Hartmut, Astarita, Jillian L., Cubas, Rafael, Jhunjhunwala

Journal:

Year:

2018

Language:

english

File:

PDF, 6.79 MB

english, 2018

2

A distinct role for Lgr5+ stem cells in primary and metastatic colon cancer

Melo, Felipe de Sousa e, Kurtova, Antonina V., Harnoss, Jonathan M., Kljavin, Noelyn, Hoeck, Joerg D., Hung, Jeffrey, Anderson, Jeffrey Eastham, Storm, Elaine E., Modrusan, Zora, Koeppen, Hartmut, Dij

Journal:

Year:

2017

Language:

english

File:

PDF, 19.03 MB

english, 2017

3

Stem cell plasticity enables hair regeneration following Lgr5+ cell loss

Hoeck, Joerg D., Biehs, Brian, Kurtova, Antonina V., Kljavin, Noelyn M., de Sousa e Melo, Felipe, Alicke, Bruno, Koeppen, Hartmut, Modrusan, Zora, Piskol, Robert, de Sauvage, Frederic J.

Journal:

Nature Cell Biology

Year:

2017

Language:

english

File:

PDF, 23.81 MB

english, 2017

4

Chromosome 18 breakpoint in t(11;18)(q21;q21) translocation associated with MALT lymphoma is proximal to BCL2 and distal to DCC

Archontoula Stoffel, Pulivarthi H. Rao, Diane C. Louie, Kenneth Krauter, David N. Liebowitz, Hartmut Koeppen, Michelle M. Le Beau, R.S.K. Chaganti

Journal:

Genes, Chromosomes and Cancer

Year:

1999

Language:

english

File:

PDF, 161 KB

english, 1999

5

Cytoplasmic localization of nucleophosmin in bone marrow blasts of acute myeloid leukemia patients is not completely concordant with NPM1 mutation and is not predictive of prognosis

Sergej Konoplev, Xuelin Huang, Harry A. Drabkin, Hartmut Koeppen, Dan Jones, Hagop M. Kantarjian, Guillermo Garcia-Manero, Weina Chen, L. Jeffrey Medeiros, Carlos E. Bueso-Ramos

Journal:

Year:

2009

Language:

english

File:

PDF, 295 KB

english, 2009

6

Cuplike nuclei (prominent nuclear invaginations) in acute myeloid leukemia are highly associated with FLT3 internal tandem duplication and NPM1 mutation

Weina Chen, Sergej Konoplev, L. Jeffrey Medeiros, Hartmut Koeppen, Vasiliki Leventaki, Saroj Vadhan-Raj, Dan Jones, Hagop M. Kantarjian, Brunangelo Falini, Carlos E. Bueso-Ramos

Journal:

Year:

2009

Language:

english

File:

PDF, 182 KB

english, 2009

7

Tumors with reduced expression of a cytotoxic T lymphocyte recognized antigen lack immunogenicity but retain sensitivity to lysis by cytotoxic T lymphocytes

Hartmut Koeppen, Maria Acena, Aimee Drolet, Donald A. Rowley, Hans Schreiber

Journal:

European Journal of Immunology

Year:

1993

Language:

english

File:

PDF, 785 KB

english, 1993

8

Quantification of tumor tissue populations by multispectral analysis

Richard A.D. Carano, Adrienne L. Ross, Jed Ross, Simon P. Williams, Hartmut Koeppen, Ralph H. Schwall, Nicholas Van Bruggen

Journal:

Magnetic Resonance in Medicine

Year:

2004

Language:

english

File:

PDF, 1.94 MB

english, 2004

9

Plasmalemmal vesicle-associated protein (PLVAP) is expressed by tumour endothelium and is upregulated by vascular endothelial growth factor-A (VEGF)

Laura A Strickland, Adrian M Jubb, Jo-Anne Hongo, Fiona Zhong, Jennifer Burwick, Ling Fu, Gretchen D Frantz, Hartmut Koeppen

Journal:

The Journal of Pathology

Year:

2005

Language:

english

File:

PDF, 542 KB

english, 2005

10

Preclinical evaluation of carcinoembryonic cell adhesion molecule (CEACAM) 6 as potential therapy target for pancreatic adenocarcinoma

Laura A Strickland, Jed Ross, Simon Williams, Sarajane Ross, Maria Romero, Susan Spencer, Rich Erickson, Julie Sutcliffe, Caroline Verbeke, Paul Polakis, Nicholas van Bruggen, Hartmut Koeppen

Journal:

The Journal of Pathology

Year:

2009

Language:

english

File:

PDF, 600 KB

english, 2009

11

Neuropilin-1 expression in cancer and development

Adrian M Jubb, Laura A Strickland, Scot D Liu, Judy Mak, Maike Schmidt, Hartmut Koeppen

Journal:

The Journal of Pathology

Year:

2012

Language:

english

File:

PDF, 624 KB

english, 2012

12

Anti-amyloidogenic Activity of IgGs Contained in Normal Plasma

Brian O’Nuallain, Angela D. Williams, Helen P. McWilliams-Koeppen, Luis Acero, Alfred Weber, Hartmut Ehrlich, Hans P. Schwarz, Alan Solomon

Journal:

Journal of Clinical Immunology

Year:

2010

Language:

english

File:

PDF, 307 KB

english, 2010

13

Molecular diagnostics of acute myeloid leukaemia

Zhuang Zuo, Pranil Chandra, Yong Hannah Wen, Hartmut Koeppen

Journal:

Diagnostic Histopathology

Year:

2009

Language:

english

File:

PDF, 203 KB

english, 2009

14

Neuropilin-2 expression in cancer

Adrian M Jubb, Susan M Sa, Navneet Ratti, Laura A Strickland, Maike Schmidt, Christopher A Callahan, Hartmut Koeppen

Journal:

Year:

2012

Language:

english

File:

PDF, 1.48 MB

english, 2012

15

Application of COLD-PCR for improved detection of KRAS mutations in clinical samples

Zuo, Zhuang, Chen, Su S, Chandra, Pranil K, Galbincea, John M, Soape, Matthew, Doan, Steven, Barkoh, Bedia A, Koeppen, Hartmut, Medeiros, L Jeffrey, Luthra, Rajyalakshmi

Journal:

Modern Pathology

Year:

2009

Language:

english

File:

PDF, 246 KB

english, 2009

16

The ubiquitin ligase COP1 is a critical negative regulator of p53

Dornan, David, Wertz, Ingrid, Shimizu, Harumi, Arnott, David, Frantz, Gretchen D., Dowd, Patrick, O' Rourke, Karen, Koeppen, Hartmut, Dixit, Vishva M.

Journal:

Year:

2004

Language:

english

File:

PDF, 579 KB

english, 2004

17

Identification and immunotherapeutic targeting of antigens induced by chemotherapy

Rubinfeld, Bonnee, Upadhyay, Archana, Clark, Suzanna L, Fong, Sharon E, Smith, Victoria, Koeppen, Hartmut, Ross, Sarajane, Polakis, Paul

Journal:

Nature Biotechnology

Year:

2006

Language:

english

File:

PDF, 374 KB

english, 2006

18

Predicting benefit from anti-angiogenic agents in malignancy

Jubb, Adrian M., Oates, Adam J., Holden, Scott, Koeppen, Hartmut

Journal:

Nature Reviews Cancer

Year:

2006

Language:

english

File:

PDF, 568 KB

english, 2006

19

MAGI-1: A Widely Expressed, Alternatively Spliced Tight Junction Protein

Richard P. Laura, Sarajane Ross, Hartmut Koeppen, Laurence A. Lasky

Journal:

Experimental Cell Research

Year:

2002

Language:

english

File:

PDF, 1021 KB

english, 2002

20

Epidermal growth factor receptor in osteosarcoma: expression and mutational analysis

Yong Hannah Wen, Hartmut Koeppen, Roberto Garcia, Luis Chiriboga, Branden D. Tarlow, Brock A. Peters, Charles Eigenbrot, Herman Yee, German Steiner, M. Alba Greco

Journal:

Human Pathology

Year:

2007

Language:

english

File:

PDF, 1.27 MB

english, 2007

21

Selective Expression of Murine Prostate Stem Cell Antigen in Fetal and Adult Tissues and the Transgenic Adenocarcinoma of the Mouse Prostate Model of Prostate Carcinogenesis

Sarajane Ross, Susan D. Spencer, Laurence A. Lasky, Hartmut Koeppen

Journal:

The American Journal of Pathology

Year:

2001

Language:

english

File:

PDF, 3.78 MB

english, 2001

22

An interleukin 12-related cytokine is up-regulated in ulcerative colitis but not in Crohn's disease

Andreas D. Christ*, Anthony C. Stevens‡, Hartmut Koeppen§, Shawn Walsh∥, Fumio Omata*, Odile Devergne¶, Mark Birkenbach§, Richard S. Blumberg*

Journal:

Gastroenterology

Year:

1998

Language:

english

File:

PDF, 293 KB

english, 1998

23

High CD21 expression inhibits internalization of anti-CD19 antibodies and cytotoxicity of an anti-CD19-drug conjugate

Gladys S Ingle, Pamela Chan, J Michael Elliott, Wesley S Chang, Hartmut Koeppen, Jean-Philippe Stephan, Suzie J Scales

Journal:

British Journal of Haematology

Year:

2008

Language:

english

File:

PDF, 565 KB

english, 2008

24

Non-hodgkin’s lymphoma presenting nine years after ileal-pouch ileoanal anastomosis for ulcerative colitis

Annette M. Winter, Hartmut Koeppen, Stephen B. Hanauer

Journal:

American Journal of Gastroenterology

Year:

1998

Language:

english

File:

PDF, 152 KB

english, 1998

25

Genetically Engineered Vaccines Comparison of Active versus Passive Immunotherapy against Solid Tumors

HARTMUT KOEPPEN, SUNANDA SINGH, HANS SCHREIBER

Journal:

Annals of the New York Academy of Sciences

Year:

1993

Language:

english

File:

PDF, 526 KB

english, 1993

26

Multimodal Microvascular Imaging Reveals that Selective Inhibition of Class I PI3K Is Sufficient to Induce an Antivascular Response

Sampath, Deepak, Oeh, Jason, Wyatt, Shelby K., Cao, Tim C., Koeppen, Hartmut, Eastham-Anderson, Jeffrey, Robillard, Liliane, Ho, Calvin C.K., Ross, Jed, Zhuang, Guanglei, Reslan, Hani Bou, Vitorino, P

Journal:

Year:

2013

Language:

english

File:

PDF, 2.78 MB

english, 2013

27

Pathology in drug discovery and development

Jubb, Adrian M, Koeppen, Hartmut, Reis-Filho, Jorge S

Journal:

The Journal of Pathology

Year:

2014

Language:

english

File:

PDF, 241 KB

english, 2014

28

Developing biomarkers to predict benefit from HGF/MET pathway inhibitors

Koeppen, Hartmut, Rost, Sandra, Yauch, Robert L

Journal:

The Journal of Pathology

Year:

2014

Language:

english

File:

PDF, 1.16 MB

english, 2014

29

Impact of MET expression on outcome in BRAF V600E/K advanced melanoma

Jubb, Adrian M, Ribas, Antoni, Sosman, Jeffrey A, McArthur, Grant A, Yan, Yibing, Rost, Sandra, Zhao, Sherry, Koeppen, Hartmut

Journal:

Year:

2013

Language:

english

File:

PDF, 480 KB

english, 2013

30

Development of a robust RNA-based classifier to accurately determine ER, PR, and HER2 status in breast cancer clinical samples

Wilson, Timothy R., Xiao, Yuanyuan, Spoerke, Jill M., Fridlyand, Jane, Koeppen, Hartmut, Fuentes, Eloisa, Huw, Ling Y., Abbas, Ilma, Gower, Arjan, Schleifman, Erica B., Desai, Rupal, Fu, Ling, Sumiyos

Journal:

Breast Cancer Research and Treatment

Year:

2014

Language:

english

File:

PDF, 715 KB

english, 2014

31

MET Suppresses Epithelial VEGFR2 via Intracrine VEGF-induced Endoplasmic Reticulum-associated Degradation

Chen, Tom T., Filvaroff, Ellen, Peng, Jing, Marsters, Scot, Jubb, Adrian, Koeppen, Hartmut, Merchant, Mark, Ashkenazi, Avi

Journal:

Year:

2015

Language:

english

File:

PDF, 2.41 MB

english, 2015

32

Acute erythroid leukemia as defined in the World Health Organization classification is a rare and pathogenetically heterogeneous disease

Kasyan, Armen, Medeiros, L Jeffrey, Zuo, Zhuang, Santos, Favio P, Ravandi-Kashani, Farhad, Miranda, Roberto, Vadhan-Raj, Saroj, Koeppen, Hartmut, Bueso-Ramos, Carlos E

Journal:

Modern Pathology

Year:

2010

Language:

english

File:

PDF, 392 KB

english, 2010

33

Long-Term Inhibition of Tumor Growth by Tumor Necrosis Factor in the Absence of Cachexia or T-Cell Immunity

Michael N. Teng, Ben H. Park, Hartmut K. W. Koeppen, Kevin J. Tracey, Brian M. Fendly and Hans Schreiber

Journal:

Proceedings of the National Academy of Sciences

Year:

1991

Language:

english

File:

PDF, 907 KB

english, 1991

34

A Highly Immunogenic Tumor Transfected with a Murine Transforming Growth Factor Type β1cDNA Escapes Immune Surveillance

Guillermo Torre-Amione, R. Daniel Beauchamp, Hartmut Koeppen, Ben H. Park, Hans Schreiber, Harold L. Moses and Donald A. Rowley

Journal:

Proceedings of the National Academy of Sciences

Year:

1990

Language:

english

File:

PDF, 1.14 MB

english, 1990

35

p21-Activated Kinase 2 Regulates Endothelial Development and Function through the Bmk1/Erk5 Pathway

Radu, Maria, Lyle, Karen, Hoeflich, Klaus P., Villamar-Cruz, Olga, Koeppen, Hartmut, Chernoff, Jonathan

Journal:

Molecular and Cellular Biology

Year:

2015

Language:

english

File:

PDF, 4.63 MB

english, 2015

36

Preclinical pharmacokinetics, pharmacodynamics, tissue distribution, and tumor penetration of anti-PD-L1 monoclonal antibody, an immune checkpoint inhibitor

Deng, Rong, Bumbaca, Daniela, Pastuskovas, Cinthia V., Boswell, C. Andrew, West, David, Cowan, Kyra J., Chiu, Henry, McBride, Jacqueline, Johnson, Clarissa, Xin, Yan, Koeppen, Hartmut, Leabman, Maya,

Journal:

Year:

2016

Language:

english

File:

PDF, 1.86 MB

english, 2016

37

High cell-surface density of HER2 deforms cell membranes

Chung, Inhee, Reichelt, Mike, Shao, Lily, Akita, Robert W., Koeppen, Hartmut, Rangell, Linda, Schaefer, Gabriele, Mellman, Ira, Sliwkowski, Mark X.

Journal:

Nature Communications

Year:

2016

Language:

english

File:

PDF, 5.86 MB

english, 2016

38

The molecular landscape of high-risk early breast cancer: comprehensive biomarker analysis of a phase III adjuvant population

Wilson, Timothy R, Yu, Jianjun, Lu, Xuyang, Spoerke, Jill M, Xiao, Yuanyuan, O’Brien, Carol, Savage, Heidi M, Huw, Ling-Yuh, Zou, Wei, Koeppen, Hartmut, Forrest, William F, Fridlyand, Jane, Fu, Ling,

Journal:

npj Breast Cancer

Year:

2016

Language:

english

File:

PDF, 2.93 MB

english, 2016

39

Characterization of PD-L1 expression and immune cell infiltration in nasopharyngeal cancer

Chan, Oscar Siu Hong, Kowanetz, Marcin, Ng, Wai Tong, Koeppen, Hartmut, Chan, Lai Kwan, Yeung, Rebecca Mei Wan, Wu, Haiyan, Amler, Lukas, Mancao, Christoph

Journal:

Year:

2017

Language:

english

File:

PDF, 2.04 MB

english, 2017

40

Tumour and host cell PD-L1 is required to mediate suppression of anti-tumour immunity in mice

Lau, Janet, Cheung, Jeanne, Navarro, Armando, Lianoglou, Steve, Haley, Benjamin, Totpal, Klara, Sanders, Laura, Koeppen, Hartmut, Caplazi, Patrick, McBride, Jacqueline, Chiu, Henry, Hong, Rebecca, Gro

Journal:

Nature Communications

Year:

2017

Language:

english

File:

PDF, 2.26 MB

english, 2017

41

P2.01-043 Pathologist Agreement Rates of PD-L1 Tumor and Immune Cell Quantitation Using Digital Read, Field-Of-View, and Whole Tumor Image Analysis

Barnes, Michael, Bai, Isaac, Nguyen, Kien, Bredno, Joerg, Vennapusa, Bharathi, Fonstad, Rachel, Agarwal, Suresh, Patil, Suhas, Little, Elizabeth, Koeppen, Hartmut, Guetter, Christoph

Journal:

Journal of Thoracic Oncology

Year:

2017

Language:

english

File:

PDF, 177 KB

english, 2017

42

Multiplexed ion beam imaging analysis for quantitation of protein expresssion in cancer tissue sections

Rost, Sandra, Giltnane, Jennifer, Bordeaux, Jennifer M, Hitzman, Chuck, Koeppen, Hartmut, Liu, Scot D

Journal:

Laboratory Investigation

Year:

2017

Language:

english

File:

PDF, 3.67 MB

english, 2017

43

Co-targeting of MEK and PDGFR/STAT3 pathways to treat pancreaticductal adenocarcinoma

Sahu, Nisebita, Chan, Emily, Chu, Felix, Pham, Thinh, Koeppen, Hartmut, Forrest, William, Merchant, Mark, Settleman, Jeff

Journal:

Molecular Cancer Therapeutics

Year:

2017

Language:

english

File:

PDF, 4.16 MB

english, 2017

44

Developing a Process Model for the Design of Assistance Components in Information Appliances

Koeppen, Norman, Wandke, Hartmut

Journal:

IFAC Proceedings Volumes

Year:

2001

Language:

english

File:

PDF, 509 KB

english, 2001

45

Molecular and Histopathological Characterization of the Tumor Immune Microenvironment in Advanced Stage of Malignant Pleural Mesothelioma

Patil, Namrata S., Righi, Luisella, Koeppen, Hartmut, Zou, Wei, Izzo, Stefania, Grosso, Federica, Libener, Roberta, Loiacono, Marco, Monica, Valentina, Buttigliero, Consuelo, Novello, Silvia, Hegde, P

Journal:

Journal of Thoracic Oncology

Year:

2017

Language:

english

File:

PDF, 11.56 MB

english, 2017

46

Association of PD-L1 expression with treatment outcomes in patients with BRAF mutation-positive melanoma treated with vemurafenib or cobimetinib combined with vemurafenib

Wongchenko, Matthew J., Ribas, Antoni, Dréno, Brigitte, Ascierto, Paolo A., McArthur, Grant A., Gallo, Jorge D., Rooney, Isabelle A., Hsu, Jessie, Koeppen, Hartmut, Yan, Yibing, Larkin, James

Journal:

Pigment Cell & Melanoma Research

Year:

2017

Language:

english

File:

PDF, 741 KB

english, 2017

47

Characterization of PD-L1 expression in Chinese non-small cell lung cancer patients with PTEN expression as a means for tissue quality screening

Zhang, Xu-chao, Cao, Xu, Sun, Chun, Xie, Zhi, Guo, Jian-jun, Yang, Jin-ji, Yang, Xue-ning, Dai, Hang-jun, Li, Su-chun, Xu, Xin-ran, Zuo, Yun-xia, Chen, Meng, Koeppen, Hartmut, He, Jing, Kiermaier, Ast

Journal:

Cancer Immunology, Immunotherapy

Year:

2017

Language:

english

File:

PDF, 1.65 MB

english, 2017

48

SUV420H2 is an epigenetic regulator of epithelial/mesenchymal states in pancreatic cancer

Viotti, Manuel, Wilson, Catherine, McCleland, Mark, Koeppen, Hartmut, Haley, Benjamin, Jhunjhunwala, Suchit, Klijn, Christiaan, Modrusan, Zora, Arnott, David, Classon, Marie, Stephan, Jean-Philippe, M

Journal:

The Journal of Cell Biology

Year:

2017

Language:

english

File:

PDF, 2.96 MB

english, 2017

49

Smad3‐mediated recruitment of the methyltransferase SETDB1/ESET controls Snail1 expression and epithelial–mesenchymal transition

Du, Dan, Katsuno, Yoko, Meyer, Dominique, Budi, Erine H, Chen, Si‐Han, Koeppen, Hartmut, Wang, Hongjun, Akhurst, Rosemary J, Derynck, Rik

Journal:

Year:

2017

Language:

english

File:

PDF, 3.50 MB

english, 2017

50

Multiplexed ion beam imaging analysis for quantitation of protein expresssion in cancer tissue sections

Rost, Sandra, Giltnane, Jennifer, Bordeaux, Jennifer M, Hitzman, Chuck, Koeppen, Hartmut, Liu, Scot D

Journal:

Laboratory Investigation

Year:

2017

File:

PDF, 37 KB

2017